Azobisisobutyronitrile → Bromo(4-fluorophenyl)acetic acid
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[Br:12]N1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N>C(Cl)(Cl)(Cl)Cl>[Br:12][CH:8]([C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1)[C:9]([OH:11])=[O:10]参加物
5
実験手順
A solution of 4-fluorophenylacetic acid (9.7 g), N-bromosuccinimide (11.2 g) and azobisisobutyronitrile (AIBN, 0.2 g) in carbontetrachloride (100 ml) was reluxed for 2 hours. After cooling it was filtered through Celite® and the filtrate was evaporated to give an oily residue of α-bromo-4-fluorophenylacetic acid, which was used for next step without purification.
後処理
- temperatureAfter cooling it
- filtrationwas filtered through Celite®
- customthe filtrate was evaporated
出典と根拠
- ORDレコード
- ord-4e825495e83c42d5bb09f376aa845f60
- 出典データセット
- uspto-grants-1996_12
- 特許番号
- US05583147
反応ノート
読み込み中…