Cyclopentanone → 1-(Methylamino)cyclopentane-1-carbonitrile
反応式
[C-:1]#[N:2].[K+].[C:4]1(=O)[CH2:8][CH2:7][CH2:6][CH2:5]1.Cl.[CH3:11][NH2:12]>O>[CH3:1][NH:2][C:4]1([C:11]#[N:12])[CH2:8][CH2:7][CH2:6][CH2:5]1参加物
5
実験手順
A solution of 6.5 of potassium cyanide in 13 ml of water was added at 15°-20° C. to a solution of 8.5 g of cyclopentanone and 7 g of methylamine hydrochloride in 7.5 ml of water and returned to room temperature; the mixture was stirred for 18 hours and extracted with methylene chloride. The organic phase was washed with aqueous sodium chloride, dried, and evaporated to dryness, and the residue was distilled to obtain 4.1 g of the expected product with a boiling point of 60° C.±0.3° C. at 7 mm of Hg.
後処理
- customreturned to room temperature
- extractionextracted with methylene chloride
- washThe organic phase was washed with aqueous sodium chloride
- customdried
- customevaporated to dryness
- distillationthe residue was distilled
出典と根拠
- ORDレコード
- ord-254ea29eb8be400f94a87657c6f1d3e6
- 出典データセット
- uspto-grants-1996_12
- 特許番号
- US05589497
反応ノート
読み込み中…