Ethyl Acetoacetate → Ethyl 3-tetrahydropyrrolyl-2-butenoate

反応式

[C:1]([O:7][CH2:8][CH3:9])(=[O:6])[CH2:2][C:3]([CH3:5])=O.[NH:10]1[CH2:14][CH2:13][CH2:12][CH2:11]1>>[NH:10]1[CH2:14][CH2:13][CH2:12][CH:11]1[C:3]([CH3:5])=[CH:2][C:1]([O:7][CH2:8][CH3:9])=[O:6]

参加物

反応物 2

HCID 8868Ethyl Acetoacetate

HCID 31268Pyrrolidine

生成物 1

HCID 69630519Ethyl 3-tetrahydropyrrolyl-2-butenoate

実験手順

Ethyl 3-tetrahydropyrrolyl-2-butenoate was prepared (21 g, 99%) from ethyl acetoacetate (15.0 g, 115.26 mmol) and pyrrolidine (71.1 mL, 345.78 mmol) in the same manner as described in the above Example 1 (1), and the obtained product was identified with the following NMR data.

出典と根拠

ORDレコード: ord-c4f6c0a039404fa9b84557e51bc4c6bf
出典データセット: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07094908B2

反応ノート

読み込み中…