Pyridine → N-(2-Bromoethyl)-p-nitrobenzamide

HRID 1085258

反応式

HRID 1085258 の反応式
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8](Cl)=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].Br.[NH2:14][CH2:15][CH2:16][Br:17].N1C=CC=CC=1>C(Cl)(Cl)Cl>[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([NH:14][CH2:15][CH2:16][Br:17])=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

5

反応物 3

HCID 1049PyridineHCID 85024-Nitrobenzoyl chlorideHCID 27742172-Bromoethylamine hydrobromide

生成物 1

HCID 458985N-(2-Bromoethyl)-p-nitrobenzamide

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

In 30 ml of chloroform were added 3 g of 4-nitrobenzoyl chloride, 3.3 g of 2-aminoethyl bromide hydrobromide and 3.9 ml of pyridine under ice cooling, and they were stirred at the same temperature for 1 hour. The reaction mixture was then washed with water, and the resulting organic layer was concentrated to obtain a crude product of 2-(4-nitrobenzoylamino)ethyl bromide. Afterward, the latter was recrystallized from hexane/ethanol, the resulting crystals were collected by filtration, washed and dried to prepare 2.9 g of 2-(4-nitrobenzoylamino)ethyl bromide (compound 46).

後処理

  1. washThe reaction mixture was then washed with water
  2. concentrationthe resulting organic layer was concentrated

出典と根拠

ORDレコード
ord-6552b384b67f4658950798dd857919fd
出典データセット
uspto-grants-1991_04
特許番号
US05008267

関連ノート

読み込み中…