Isobutyrophenone → 2-Methyl-1-phenyl-1-propanol

HRID 1086019

反応式

HRID 1086019 の反応式
[BH4-].[Na+].[C:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:7])[CH:4]([CH3:6])[CH3:5]>C(O)C>[CH3:5][CH:4]([CH3:6])[CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[OH:7]

参加物

4

反応物 2

HCID 69144IsobutyrophenoneHCID 4311764Sodium borohydride

生成物 1

HCID 956262-Methyl-1-phenyl-1-propanol収率 94%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Sodium borohydride (6.5 g, 0.17 mol) was added in portions over a 2 h period to a solution of isobutyrophenone (50 g, 0.34 mol) in ethanol (150 mL) under nitrogen. The reaction mixture was stirred at room temperature for 2 h. Ethanol was removed under reduced pressure. The reaction mixture was added to water (100 mL) and extracted with methylene chloride (3×100 mL). The organic extract was collected, dried (anhy. MgSO4), and concentrated to give 2-methyl-1-phenyl-1-propanol (48 g, 94% yield): bp 62° C. at 0.1 mm; 1H NMR (CDC13) 0.75 (d, J=7, 3 H), 0.96 (d, J=7, 3 H), 1.98 (m, 1 H), 2.90 (bs, 1 H), 4.25 (d, J=7, 1 H), and 7.31 (s, 5 H).

後処理

  1. customEthanol was removed under reduced pressure
  2. additionThe reaction mixture was added to water (100 mL)
  3. extractionextracted with methylene chloride (3×100 mL)
  4. extractionThe organic extract
  5. customwas collected
  6. customdried (anhy
  7. concentrationMgSO4), and concentrated

出典と根拠

ORDレコード
ord-364f3b6e711f42359dae904977646017
出典データセット
uspto-grants-1991_04
特許番号
US05012007

関連ノート

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