Water → 4-Methyl-2-undecyl-2-oxazoline-4-methanol

HRID 1086426ノート

反応式

HRID 1086426 の反応式
[C:1]([OH:14])(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[NH2:15][C:16]([CH3:21])([CH2:19]O)[CH2:17][OH:18].O>C1(C)C(C)=CC=CC=1.C(OCC)(=O)C>[OH:18][CH2:17][C:16]1([CH3:21])[CH2:19][O:14][C:1]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])=[N:15]1

参加物

6

反応物 3

HCID 962WaterHCID 15312-Amino-2-methyl-1,3-propanediolHCID 3893Lauric Acid

生成物 1

HCID 735074-Methyl-2-undecyl-2-oxazoline-4-methanol収率 84.6%

試薬・触媒・溶媒 2

HCID 7237O-Xylene溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 20.03 g (100 mmoles) of dodecanoic acid and 11.57 g (110) mmoles) of 2-amino-2-methyl-1,3-propanediol in 10 ml of xylene was heated for 30 hours at 185°-190° C. with azeotropic removal of water. The reaction mixture was taken up in ethyl acetate and was washed with water to remove excess amino alcohol. The organic layer was dried, concentrated and the residue was distilled at 152°-155° C./1 mm Hg to give 22.8 g (84.6%) of 4-hydroxymethyl-4-methyl-2-undecyl-2-oxazoline.

後処理

  1. washwas washed with water
  2. customto remove excess amino alcohol
  3. customThe organic layer was dried
  4. concentrationconcentrated
  5. distillationthe residue was distilled at 152°-155° C./1 mm Hg

出典と根拠

ORDレコード
ord-9176830619b64ac88ef7d939db3bed6d
出典データセット
uspto-grants-1991_07
特許番号
US05030629

反応ノート

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