Ethanol → 2-(1-Hydroximinoethyl)phenoxathiin

HRID 1087379

反応式

HRID 1087379 の反応式
[C:1]([C:4]1[CH:17]=[CH:16][C:15]2[O:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[S:7][C:6]=2[CH:5]=1)(=O)[CH3:2].Cl.[NH2:19][OH:20].C(O)C>N1C=CC=CC=1>[N:19](=[C:1]([C:4]1[CH:17]=[CH:16][C:15]2[O:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[S:7][C:6]=2[CH:5]=1)[CH3:2])[OH:20]

参加物

5

反応物 3

HCID 702EthanolHCID 443297Hydroxyamine hydrochlorideHCID 5151742-Acetylphenoxathiin

生成物 1

HCID 5151822-(1-Hydroximinoethyl)phenoxathiin収率 90.4%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A mixture of 2-acetylphenoxathiin (J.A.C.S. 1936, 58, 717) (484 mg, 2 mmol), hydroxylamine hydrochloride (556 mg, 8 mmol), ethanol (8 mL) and pyridine (4 mL) was stirred at room temperature for 45 minutes. The ethanol was evaporated and the residue triturated with water until a solid was obtained. Filtration afforded the title oxime (465 mg) as a cream-colored solid, m.p.: 143°-148° C.

後処理

  1. customThe ethanol was evaporated
  2. customthe residue triturated with water until a solid
  3. customwas obtained
  4. filtrationFiltration

出典と根拠

ORDレコード
ord-5c2ab80badb14bad881eb7da742595e0
出典データセット
uspto-grants-1991_07
特許番号
US05036067

関連ノート

読み込み中…