Benzo(d)thiazol-2-amine → N-Benzothiazol-2-yl-2-methoxy-acetamide

HRID 1087458ノート

反応式

HRID 1087458 の反応式
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:11][O:12][CH2:13][C:14](Cl)=[O:15]>N1C=CC=CC=1>[CH3:11][O:12][CH2:13][C:14]([NH:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1)=[O:15]

参加物

4

反応物 2

HCID 8706Benzo(d)thiazol-2-amineHCID 96623Methoxyacetyl chloride

生成物 1

HCID 667540N-Benzothiazol-2-yl-2-methoxy-acetamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

2-Aminobenzothiazole (4.5 g) is dissolved in pyridine (100 ml) and thereto is added dropwise methoxyacetyl chloride (3.0 ml) at room temperature. After the mixture is stirred at room temperature for 2 hours, the solvent is distilled off. The resulting oil is dissolved in chloroform and the organic layer is washed with water and then with a saturated saline. The organic layer is dried over anhydrous sodium sulfate and the solvent is distilled off. The resulting solids are recrystallized from ethanol/water to give the title compound (5.2 g) having the following physical properties.

後処理

  1. distillationthe solvent is distilled off
  2. dissolutionThe resulting oil is dissolved in chloroform
  3. washthe organic layer is washed with water
  4. dry with materialThe organic layer is dried over anhydrous sodium sulfate
  5. distillationthe solvent is distilled off
  6. customThe resulting solids are recrystallized from ethanol/water

出典と根拠

ORDレコード
ord-3e43672404ed4e4bbeb2b2ceb84a8e92
出典データセット
uspto-grants-1991_07
特許番号
US05036086

反応ノート

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