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N,N-Dimethylethylenediamine → 4-(3,4-Dichlorophenyl)-N-[2-(dimethylamino)ethyl]-1-piperazinecarboxamide

HRID 1087829
ノート
印刷プレビュー

反応式

HRID 1087829 の反応式
[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6](N1CCN(C2C=CC(F)=CC=2)CC1)=[O:7].C(N1C=CN=C1)(N1C=CN=C1)=O.CN(CCN)C.[Cl:40][C:41]1[CH:42]=[C:43]([N:48]2[CH2:53][CH2:52][NH:51][CH2:50][CH2:49]2)[CH:44]=[CH:45][C:46]=1[Cl:47]>O1CCCC1>[Cl:40][C:41]1[CH:42]=[C:43]([N:48]2[CH2:53][CH2:52][N:51]([C:6]([NH:5][CH2:4][CH2:3][N:2]([CH3:21])[CH3:1])=[O:7])[CH2:50][CH2:49]2)[CH:44]=[CH:45][C:46]=1[Cl:47]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 66053N,N-DimethylethylenediamineHCID 682631,1'-CarbonyldiimidazoleHCID 936011-(3,4-Dichlorophenyl)piperazineHCID 14763463N-[2-(Dimethylamino)ethyl]-4-(4-fluorophenyl)-1-piperazinecarboxamide

生成物 1

HCID 147634864-(3,4-Dichlorophenyl)-N-[2-(dimethylamino)ethyl]-1-piperazinecarboxamide

試薬・触媒・溶媒 1

HCID 8028
Tetrahydrofuran
溶媒

実験手順

This compound was prepared according to the procedure used to synthesize the compound of Example 11. A mixture of 2.5 g (0.025 mole) of 1,1'-carbonyldiimidazole, 1.4 g (0.015 mole) of unsym-dimethylethylenediamine and 3.6 g (0.015 mole) of 1-(3,4-dichlorophenyl)piperazine in a total of 100 ml of tetrahydrofuran gave an oil which solidified when triturated with cyclohexane. White solid, the title compound, in the amount of 4.0 g (75%) was collected, m.p. 80°-83° C.

後処理

  1. customThis compound was prepared
  2. customgave an oil which
  3. customtriturated with cyclohexane
  4. customWhite solid, the title compound, in the amount of 4.0 g (75%) was collected

出典と根拠

ORDレコード
ord-825f4b0ba7684fc7bde3a17d439c4288
出典データセット
uspto-grants-1990_10
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04960776

反応ノート

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