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Hydrochloric Acid → 4-(3,4-Dimethoxyphenyl)-N-[2-(dimethylamino)ethyl]-1-piperazinecarboxamide hydrochloride

HRID 1087831
ノート
印刷プレビュー

反応式

HRID 1087831 の反応式
[CH3:1][N:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6](N1CCN(C2C=CC(F)=CC=2)CC1)=[O:7].C(N1C=CN=C1)(N1C=CN=C1)=O.CN(CCN)C.[CH3:40][O:41][C:42]1[CH:43]=[C:44]([N:50]2[CH2:55][CH2:54][NH:53][CH2:52][CH2:51]2)[CH:45]=[CH:46][C:47]=1[O:48][CH3:49].[ClH:56]>O1CCCC1>[ClH:56].[CH3:40][O:41][C:42]1[CH:43]=[C:44]([N:50]2[CH2:51][CH2:52][N:53]([C:6]([NH:5][CH2:4][CH2:3][N:2]([CH3:21])[CH3:1])=[O:7])[CH2:54][CH2:55]2)[CH:45]=[CH:46][C:47]=1[O:48][CH3:49]
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 5

HCID 313Hydrochloric AcidHCID 66053N,N-DimethylethylenediamineHCID 682631,1'-CarbonyldiimidazoleHCID 27362071-(3,4-Dimethoxyphenyl)piperazineHCID 14763463N-[2-(Dimethylamino)ethyl]-4-(4-fluorophenyl)-1-piperazinecarboxamide

生成物 1

HCID 221637894-(3,4-Dimethoxyphenyl)-N-[2-(dimethylamino)ethyl]-1-piperazinecarboxamide hydrochloride

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

This compound was prepared according to the procedure used to synthesize the compound of Example 11. A mixture of 1.6 g (0.01 mole) of 1,1'-carbonyldiimidazole, 0.87 g (0.01 mole) of unsym-dimethylethylenediamine, and 2.2 g (0.01 mole) of 1-(3,4-dimethoxyphenyl)piperazine in a total volume of 50 ml of tetrahydrofuran gave an oil as residue. The hydrochloride was formed in ethereal hydrogen chloride and the collected solid was recrystallized twice from methanolethyl ether to yield 2.3 g (57%) of the title compound as an off-white solid, m.p. 208°-210° C.

後処理

  1. customThis compound was prepared
  2. customgave an oil as residue

出典と根拠

ORDレコード
ord-00e881a7eb4e4ff894ad2763a577617e
出典データセット
uspto-grants-1990_10
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04960776

反応ノート

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