Trifluoroacetic acid → HCID 178480378、化合物

HRID 1088036ノート

反応式

HRID 1088036 の反応式
[I-].C(OC([NH:9][C@@H:10]1[C:40](=[O:41])[N:12]2[C:13]([C:24]([O:26]C(C3C=CC=CC=3)C3C=CC=CC=3)=[O:25])=[C:14]([CH2:17][N+:18]3[N:19]([CH3:23])[CH:20]=[CH:21][CH:22]=3)[CH2:15][S:16][C@H:11]12)=O)(C)(C)C.C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O.C(OC(C)C)(C)C>C(Cl)Cl>[NH2:9][C@@H:10]1[C:40](=[O:41])[N:12]2[C:13]([C:24]([O-:26])=[O:25])=[C:14]([CH2:17][N+:18]3[N:19]([CH3:23])[CH:20]=[CH:21][CH:22]=3)[CH2:15][S:16][C@H:11]12

参加物

6

反応物 4

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 7914Diisopropyl EtherHCID 178480376HCID 178480376、化合物

生成物 1

HCID 178480378HCID 178480378、化合物収率 176.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of benzhydryl 7β-tert-butoxycarbonylamino-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate iodide (22.3 g) and anisole (22 ml) in methylene chloride (66 ml) was added trifluoroacetic acid (44 ml) under ice-cooling. After the mixture was stirred at ambient temperature for an hour, the reaction mixture was added dropwise to diisopropyl ether (600 ml). The resultant precipitates were collected by filtration to give bis(trifluoroacetic acid) salts of 7β-amino-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate (16.83 g).

後処理

  1. temperaturecooling
  2. customThe resultant precipitates
  3. filtrationwere collected by filtration

出典と根拠

ORDレコード
ord-5552ce834cae42f987202fae7c703421
出典データセット
uspto-grants-1990_10
特許番号
US04960766

反応ノート

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