Hydrochloric Acid → 4,4-Dimethylpent-2-ynoic acid

HRID 1088200ノート

反応式

HRID 1088200 の反応式
[OH-:1].[Na+].Br[C:4]1(Br)[C:8](=[O:9])NN[CH:5]1[C:10]([CH3:13])([CH3:12])[CH3:11].C(#N)C.Cl>O>[CH3:11][C:10]([CH3:13])([CH3:12])[C:5]#[C:4][C:8]([OH:1])=[O:9]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 6342AcetonitrileHCID 14798Sodium HydroxideHCID 14324492HCID 14324492、化合物

生成物 1

HCID 128402174,4-Dimethylpent-2-ynoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
5 °C

実験手順

552 g of sodium hydroxide was dissolved in 3.0 liters of water and ice was added thereto to adjust the temperature to 5° C. or lower. Next, while stirring, dibromo-3-t-butyl-5-pyrazolidone was added thereto little by little while maintaining the temperature at 5° C. or lower. If the temperature would rise, ice was added, and acetonitrile was added in order to prevent foaming. After the completion of the reaction, 6 N hydrochloric acid was added to make the reaction solution acidic, and then the solution was subjected to extraction twice with ethyl acetate.

後処理

  1. additionice was added
  2. customto 5° C.
  3. additionice was added
  4. additionwas added
  5. extractionthe solution was subjected to extraction twice with ethyl acetate

出典と根拠

ORDレコード
ord-ad9b8d490d37414fb2af5949efc4ae50
出典データセット
uspto-grants-1990_10
特許番号
US04962017

反応ノート

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