Phosgene → 1,4-Dihydro-2H-3,1-benzoxazin-2-one

HRID 1088791

反応式

HRID 1088791 の反応式
[OH:1][CH2:2][C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH2:5].C(N(CC)CC)C.[C:17](Cl)(Cl)=[O:18].ClC(OC(Cl)(Cl)Cl)=O>O1CCCC1>[O:18]=[C:17]1[O:1][CH2:2][C:3]2[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=2[NH:5]1

参加物

6

反応物 4

HCID 6371PhosgeneHCID 8471TriethylamineHCID 10426DiphosgeneHCID 214392-Aminobenzyl alcohol

生成物 1

HCID 257861,4-Dihydro-2H-3,1-benzoxazin-2-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a mixture of 2-hydroxymethylaniline (25 g), triethylamine (32 ml) and tetrahydrofuran (250 ml) was introduced phosgene generated from trichloromethyl chloroformate (12.2 ml) and active carbon at room temperature with stirring. After stirring for 1 hour at room temperature, the reaction mixture was filtered off and the filtrate was concentrated. The resulting residue was recrystallized from diethyl ether-n-hexane to give 4H-1,2-dihydro-2-oxo-[3,1]benzoxazine (22.3 g).

後処理

  1. stirringAfter stirring for 1 hour at room temperature
  2. filtrationthe reaction mixture was filtered off
  3. concentrationthe filtrate was concentrated
  4. customThe resulting residue was recrystallized from diethyl ether-n-hexane

出典と根拠

ORDレコード
ord-81193c6e07db4bf5abd99c9d96cdb676
出典データセット
uspto-grants-1990_10
特許番号
US04963566

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