Sodium Hydroxide → HCID 178421631、化合物

HRID 1089919

反応式

HRID 1089919 の反応式
CO[C:3]1[C:12]2[C:7](=[C:8]([CH3:20])[C:9]3[NH:15][C:14]4[CH:16]=[CH:17][N:18]=[CH:19][C:13]=4[C:10]=3[CH:11]=2)[CH:6]=[CH:5][N:4]=1.[Cl:21]P(=O)(Cl)C1C=CC=CC=1.[OH-].[Na+]>>[Cl:21][C:3]1[C:12]2[C:7](=[C:8]([CH3:20])[C:9]3[NH:15][C:14]4[CH:16]=[CH:17][N:18]=[CH:19][C:13]=4[C:10]=3[CH:11]=2)[CH:6]=[CH:5][N:4]=1

参加物

4

反応物 3

HCID 14798Sodium HydroxideHCID 69990Phenylphosphonic dichlorideHCID 1102171610-methoxy 6-methyl 5H-pyrido[3',4':4,5]pyrrolo[2,3-g]isoquinoline

生成物 1

HCID 178421631HCID 178421631、化合物収率 54.2%

反応条件

温度
160 °C

実験手順

1.053 g (0.004 mole) of 10-methoxy 6-methyl 5H-pyrido[3',4':4,5]pyrrolo[2,3-g]isoquinoline are suspended in 5.6 ml (0.040 mole) of dichlorophenylphosphine oxide and the suspension is heated at 160° C. for 2 hours. The reaction mixture is poured onto ice and the pH is brought to 7 by the addition of 10N sodium hydroxide. After filtration and drying of the precipitate formed, 0.580 g of 10-chloro 6-methyl 5H-pyrido[3',4':4,5]pyrrolo[2,3-g]isoquinoline are obtained.

後処理

  1. additionThe reaction mixture is poured onto ice
  2. filtrationAfter filtration
  3. customdrying of the precipitate
  4. customformed

出典と根拠

ORDレコード
ord-08169c61c9704b24a6bef8b60afbebe0
出典データセット
uspto-grants-1992_01
特許番号
US05079363

関連ノート

読み込み中…