Sodium Hydroxide → 4-(quinolin-2-ylmethoxy)benzoic Acid

HRID 1090793

反応式

HRID 1090793 の反応式
C[O:2][C:3](=[O:22])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=2)=[CH:6][CH:5]=1.[OH-].[Na+]>C(O)C>[N:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:20]=[CH:21][C:12]=1[CH2:11][O:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:22])=[O:2])=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 19934817Methyl 4-(2-quinolinylmethoxy)benzoate

生成物 1

HCID 98385524-(quinolin-2-ylmethoxy)benzoic Acid収率 65.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

5.00 g of methyl-4-(quinolin-2-ylmethoxy)benzoate is dissolved in 120 ml of ethanol and 90 ml of 1N sodium hydroxide and the mixture is stirred at room temperature for 4 days. The mixture is concentrated in vacuo to remove the ethanol. The residue is diluted with water, acidified to pH 6 and the resulting solid is filtered off and recrystallized from methanol to give 3.12 g 4-(quinolin-2-ylmethoxy)benzoic acid.

後処理

  1. concentrationThe mixture is concentrated in vacuo
  2. customto remove the ethanol
  3. additionThe residue is diluted with water
  4. filtrationthe resulting solid is filtered off
  5. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-813a8b5498a34ca9a99a75095311e39c
出典データセット
uspto-grants-1992_01
特許番号
US05082849

関連ノート

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