Trifluoroacetic acid → HCID 21990122、化合物
反応式
C([N:14]1[CH2:17][CH:16]([OH:18])[CH2:15]1)(C1C=CC=CC=1)C1C=CC=CC=1.[C:19]([OH:25])([C:21]([F:24])([F:23])[F:22])=[O:20]>CO.[OH-].[Pd+2].[OH-]>[F:22][C:21]([F:24])([F:23])[C:19]([OH:25])=[O:20].[OH:18][CH:16]1[CH2:17][NH:14][CH2:15]1参加物
5
実験手順
1-Benzhydryl-3-hydroxyazetidine (3.0 g, 12.6 mmol) was dissolved in methanol (60 mL), and 10 mL of TFA and 10% palladium hydroxide (1.0 g) were added thereto. The mixture was stirred for 24 hours under a hydrogen stream at normal pressure. The catalyst was removed by filtration, water (100 mL) was added to the filtrate, and the mixture was washed three times with ether. The aqueous layer was concentrated under reduced pressure, and the title compound (2.33 g, 99%) was obtained as an amorphous matter.
後処理
- customThe catalyst was removed by filtration, water (100 mL)
- additionwas added to the filtrate
- washthe mixture was washed three times with ether
- concentrationThe aqueous layer was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-7a736cebb3d94cfc9ed81b37c1b4d49a
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08129366B2
反応ノート
読み込み中…