Hydrochloric Acid → HCID 66593501、化合物

HRID 1091663ノート

反応式

HRID 1091663 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][C:11]#[N:12].[H-].[Na+].Cl[C:16]1[N:21]=[CH:20][CH:19]=[CH:18][N:17]=1.Cl>C1COCC1.O>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]1=[C:10]([C:16]1[N:21]=[CH:20][CH:19]=[CH:18][N:17]=1)[C:11]#[N:12]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 24758Sodium hydrideHCID 744042-ChloropyrimidineHCID 3424652-(1,3-Benzothiazol-2-yl)acetonitrile

生成物 1

HCID 66593501HCID 66593501、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

2-(Benzothiazol-2-yl)acetonitrile (0.69 g, 4 mmol) was added in portions to a suspension of 95% sodium hydride ((0.21 g, 6 mmol) in THF (12 mL). The resulting yellow suspension was stirred at room temperature for 30 min, and 2-chloropyrimidine (0.45 g, 4 mmol) was added. The mixture was stirred for 3 d, and water was added to the dark solution. The mixture was acidified with 1N hydrochloric acid, and the precipitate that formed was collected by filtration, washed with water and acetonitrile, and dried under vacuum to give 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetonitrile as a brown solid.

後処理

  1. stirringThe mixture was stirred for 3 d
  2. customthe precipitate that formed
  3. filtrationwas collected by filtration
  4. washwashed with water and acetonitrile
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-37ea5497767e4de7b014945facdd8c4a
出典データセット
uspto-grants-2012_03
特許番号
US08129396B2

反応ノート

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