Tetrabutylammonium Fluoride → 4-(1H-Pyrrol-3-ylmethyl)-morpholine

HRID 1093973

反応式

HRID 1093973 の反応式
C([Si](C(C)C)(C(C)C)[N:5]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[CH:6]1)(C)C.[N+](CCCC)(CCCC)(CCCC)CCCC.[F-]>C1COCC1>[NH:5]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)=[CH:6]1

参加物

4

反応物 2

HCID 2724141Tetrabutylammonium FluorideHCID 666367604-(1-Triisopropylsilanyl-1H-pyrrol-3-ylmethyl)-morpholine

生成物 1

HCID 575870184-(1H-Pyrrol-3-ylmethyl)-morpholine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
0 °C

実験手順

To a solution of the compound obtained in Step A (75 mmoles) in THF (100 ml) there is added, dropwise, at 0° C., Bu4NF 1.0M in THF (75.0 mmoles). After stirring at 0° C. for one hour, the solution is poured onto ice and is then extracted with DCM. The organic phases are combined and then washed with saturated aqueous NaCl solution, dried over sodium sulphate, filtered and evaporated to dryness to yield the title product, which is used directly in the next Step.

後処理

  1. customat 0° C.
  2. additionthe solution is poured onto ice
  3. extractionis then extracted with DCM
  4. washwashed with saturated aqueous NaCl solution
  5. dry with materialdried over sodium sulphate
  6. filtrationfiltered
  7. customevaporated to dryness

出典と根拠

ORDレコード
ord-d73769b6873c49feb8d2191713e330e3
出典データセット
uspto-grants-2012_03
特許番号
US08133889B2

関連ノート

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