Chloroform → (4-chloro-2-phenyl-2H-pyrazolo[3,4-c]quinolin-1-yl)acetyl chloride

HRID 1095364ノート

反応式

HRID 1095364 の反応式
O=[C:2]1[C:11]2=[N:12][N:13]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:14](CC(O)=O)=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[NH:3]1.[C:25](Cl)(=O)[C:26]([Cl:28])=[O:27].C(Cl)(Cl)[Cl:32]>CN(C=O)C>[Cl:32][C:2]1[C:11]2=[N:12][N:13]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:14]([CH2:25][C:26]([Cl:28])=[O:27])=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1

参加物

5

反応物 3

HCID 6212ChloroformHCID 65578Oxalyl chlorideHCID 57446227HCID 57446227、化合物

生成物 1

HCID 57446229(4-chloro-2-phenyl-2H-pyrazolo[3,4-c]quinolin-1-yl)acetyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide触媒

実験手順

(4-Oxo-2-phenyl-4,5-dihydro-2H-pyrazolo[3,4-c]quinolin-1-yl)acetic acid (8.83 g, 27.7 mmol) was suspended in 175 mL of chloroform. Twenty drops of DMF were added followed by oxalyl chloride (7.2 mL, 83.0 mmol). The reaction mixture was stirred at ambient temperature for 1 hour and concentrated under reduced pressure at 40° C. to afford crude (4-chloro-2-phenyl-2H-pyrazolo[3,4-c]quinolin-1-yl)acetyl chloride.

後処理

  1. concentrationconcentrated under reduced pressure at 40° C.

出典と根拠

ORDレコード
ord-c565a5dbc7444008a13ab7c0be721eab
出典データセット
uspto-grants-2012_03
特許番号
US08138173B2

反応ノート

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