Diisopropylethylamine → 3-(2-(1H-1,2,3-Triazol-1-yl)ethyl)-5-fluoro-1H-indole

HRID 1095514ノート

反応式

HRID 1095514 の反応式
Br[CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:13])[CH:11]=2)[NH:6][CH:5]=1.[NH:14]1[CH:18]=[CH:17][N:16]=[N:15]1.C(N(C(C)C)C(C)C)C>C(Cl)(Cl)Cl>[N:14]1([CH2:2][CH2:3][C:4]2[C:12]3[C:7](=[CH:8][CH:9]=[C:10]([F:13])[CH:11]=3)[NH:6][CH:5]=2)[CH:18]=[CH:17][N:16]=[N:15]1

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 112072263-(2-bromoethyl)-5-fluoro-1H-indoleHCID 178418936HCID 178418936、化合物

生成物 1

HCID 574751383-(2-(1H-1,2,3-Triazol-1-yl)ethyl)-5-fluoro-1H-indole

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A solution of 3-(2-bromo-ethyl)-5-fluoro-1H-indole (7.26 g, 30 mmol), 1,2,3-triazole (2.07 g, 30 mmol) and ethyl-diisopropylamine (5.1 ml, 30 mmol) in abs. chloroform (70 ml) was boiled under reflux for 24 h. The reaction solution was then washed twice with water, dried over Na2SO4 and concentrated i. vac. and the residue which remained was purified by flash chromatography with EA/cyclohexane (1:1→4:1).).

後処理

  1. temperatureunder reflux for 24 h
  2. washThe reaction solution was then washed twice with water
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated i
  5. customand the residue which remained was purified by flash chromatography with EA/cyclohexane (1:1→4:1)

出典と根拠

ORDレコード
ord-7e91131777cc46caab60710ed4e1658c
出典データセット
uspto-grants-2012_03
特許番号
US08138187B2

反応ノート

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