1,1'-Carbonyldiimidazole → 2H-Benzimidazol-2-one, 1,3-dihydro-1-(2-methoxyethyl)-
反応式
[CH3:1][O:2][CH2:3][CH2:4][NH:5][C:6]1[C:7]([NH2:12])=[CH:8][CH:9]=[CH:10][CH:11]=1.C1N=CN([C:18](N2C=NC=C2)=[O:19])C=1>C1COCC1>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[NH:12][C:18]1=[O:19]参加物
4
実験手順
The residue 109B (422 mg, 2.54 mmol) was dissolved in THF (7.5 mL). CDI (494 mg, 3.05 mmol) in THF (7.6 mL) was added slowly via addition funnel. After addition the mixture was stirred overnight at room temperature, solvent was removed under vacuum. The residue was purified by column chromatography (5% MeOH/DCM) to give the product 1-(2-methoxyethyl)-1H-benzo[d]imidazol-2(3H)-one (109C) as an orange solid (449 mg, 92%). ESI-MS:m/z 193.3 (M+H)+.
後処理
- additionAfter addition the mixture
- customsolvent was removed under vacuum
- customThe residue was purified by column chromatography (5% MeOH/DCM)
出典と根拠
- ORDレコード
- ord-4ede0777ad9f4c1ba9201627499b8712
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08138168B1
反応ノート
読み込み中…