Hydrazine hydrate (1:1) → Methyl 2-fluoro-4-(3-hydrazino-1,2,4-triazin-6-yl)benzoate
反応式
[F:1][C:2]1[CH:11]=[C:10]([C:12]2[N:17]=[N:16][C:15](S(C)=O)=[N:14][CH:13]=2)[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].O.[NH2:22][NH2:23]>O1CCCC1>[F:1][C:2]1[CH:11]=[C:10]([C:12]2[N:17]=[N:16][C:15]([NH:22][NH2:23])=[N:14][CH:13]=2)[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]参加物
4
実験手順
To a suspension of methyl 2-fluoro-4-[3-(methylsulfinyl)-1,2,4-triazin-6-yl]benzoate (0.19 g, 0.00064 mol) in tetrahydrofuran (20 mL) was added hydrazine hydrate (63 μL, 0.0013 mol) slowly. The mixture was stirred at RT for 1.5 h. The mixture was concentrated under reduced pressure to yield the desired product. Analytical LCMS: (M+H)+=264.1.
後処理
- concentrationThe mixture was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-1e208e898c0143d2a82c38f548f32398
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08143251B2
反応ノート
読み込み中…