Ethylene Glycol → 2-Hydroxyethyl N-methyl-N-phenylglycinate

HRID 1105776

反応式

HRID 1105776 の反応式
[CH2:1]([OH:4])[CH2:2][OH:3].[CH3:5][N:6]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:7][C:8](OCC)=[O:9].C[O-].[Na+].Cl>O>[CH3:5][N:6]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:7][C:8]([O:3][CH2:2][CH2:1][OH:4])=[O:9]

参加物

6

反応物 4

HCID 174Ethylene GlycolHCID 313Hydrochloric AcidHCID 265936(Methyl-phenyl-amino)-acetic acid ethyl esterHCID 10942334Sodium Methoxide

生成物 1

HCID 205549612-Hydroxyethyl N-methyl-N-phenylglycinate

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
150 °C

実験手順

Into a 100 ml. flask fitted with a condenser and a Dean-Stark trap there were placed 49.5 gms. ethylene glycol, 17 gms. of ethyl N-methyl-N-phenylglycinate and 0.7 gm. sodium methoxide. The flask and contents were heated to 150° C. in an oil bath and stirred for 13 hours. The reaction mixture was allowed to cool to room temperature and 1.25 ml. of concentrated HCl in 3.5 ml. water were added and the mixture was stirred for 10 minutes. After the ethylene glycol was distilled off at atmospheric pressure, 11.5 gms. of product was obtained by vacuum distillation, b.p. (0.3 mm.) 139°-149° C.

後処理

  1. customflask fitted with a condenser
  2. temperatureto cool to room temperature
  3. stirringthe mixture was stirred for 10 minutes
  4. distillationAfter the ethylene glycol was distilled off at atmospheric pressure, 11.5 gms
  5. customof product was obtained by vacuum distillation, b.p
  6. custom(0.3 mm.) 139°-149° C.

出典と根拠

ORDレコード
ord-a42ba69b9911477aacbdbc293192e764
出典データセット
uspto-grants-1982_01
特許番号
US04310512

関連ノート

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