Dimethylformamide → HCID 178475082、化合物

HRID 1106121ノート

反応式

HRID 1106121 の反応式
[C:1]([NH:4][C@@H:5]([C:9]([NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[N:23]=[C:22]([OH:24])[C:21]([C:25]([OH:27])=[O:26])=[CH:20][N:19]=2)=[CH:14][CH:13]=1)=[O:10])[CH:6]([CH3:8])[CH3:7])(=[O:3])[CH3:2].C(N1C=CN=C1)(N1C=CN=C1)=O.CN(C)C=O.O1CCCC1>CCOCC>[N-:23]1[CH:22]=[CH:21][N:19]=[CH:18]1.[C:1]([NH:4][C@@H:5]([C:9]([NH:11][C:12]1[CH:13]=[CH:14][C:15]([C:18]2[N:23]=[C:22]([OH:24])[C:21]([C:25]([OH:27])=[O:26])=[CH:20][N:19]=2)=[CH:16][CH:17]=1)=[O:10])[CH:6]([CH3:8])[CH3:7])(=[O:3])[CH3:2]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 682631,1'-CarbonyldiimidazoleHCID 178475081HCID 178475081、化合物

生成物 1

HCID 178475082HCID 178475082、化合物収率 119.7%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 3.72 g (10 mmol) of the above pyrimidine acid, 3.24 g (20 mmol) of carbonyldiimidazole, and 25 ml of dimethylformamide is stirred at 49°-52° C. for 30 min. The solution is treated with 50 ml of tetrahydrofuran and 200 ml of ether and stored in the cold overnight. The solid is filtered, washed with ether and dried to give 2.63 g of the title imidazolide.

後処理

  1. customstored in the cold overnight
  2. filtrationThe solid is filtered
  3. washwashed with ether
  4. customdried

出典と根拠

ORDレコード
ord-d903c78d1c674dc4ab52fe6ef1beb73c
出典データセット
uspto-grants-1982_01
特許番号
US04311699

反応ノート

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