Ethylene Glycol → 2-(2-Bromoethyl)-2-methyl-1,3-dioxolane
反応式
[Br:1][CH2:2][CH2:3][C:4](=[O:6])[CH3:5].[CH2:7](O)[CH2:8][OH:9].C1(C)C=CC(S(O)(=O)=O)=CC=1.C(=O)([O-])[O-].[K+].[K+]>C(OCC)(=O)C.O.C1(C)C=CC=CC=1>[CH2:8]1[O:9][C:4]([CH2:3][CH2:2][Br:1])([CH3:5])[O:6][CH2:7]1参加物
8
実験手順
A mixture of 75 g of 4-bromo-2-butanone, 40 g of ethylene glycol, 250 mg of p-toluenesulfonic acid acid and 500 ml of toluene is refluxed for about 4-6 hours under a Dean-Stark water trap. The mixture is cooled, poured into ethyl acetate and dilute potassium carbonate solution. The organic layer is separated, washed with water, dried over sodium sulfate, stripped of solvent and the residue is distilled under reduced pressure to give the title product.
後処理
- temperatureThe mixture is cooled
- customThe organic layer is separated
- washwashed with water
- dry with materialdried over sodium sulfate
- distillationthe residue is distilled under reduced pressure
出典と根拠
- ORDレコード
- ord-5579699143fc4414b844206821a3455e
- 出典データセット
- uspto-grants-1982_01
- 特許番号
- US04312994
反応ノート
読み込み中…
