8-(3-Fluorophenyl)-1,4-dioxaspiro[4.5]dec-7-ene → 8-(3-Fluorophenyl)-1,4-dioxaspiro[4.5]decane

HRID 1106375ノート

反応式

HRID 1106375 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH2:17][CH2:16][C:11]3([O:15][CH2:14][CH2:13][O:12]3)[CH2:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1>C1COCC1.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([CH:8]2[CH2:17][CH2:16][C:11]3([O:12][CH2:13][CH2:14][O:15]3)[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 187879328-(3-Fluorophenyl)-1,4-dioxaspiro[4.5]dec-7-ene

生成物 1

HCID 187879268-(3-Fluorophenyl)-1,4-dioxaspiro[4.5]decane

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

306.3 g of 8-(3-fluorophenyl)-1,4-dioxaspiro[4.5]dec-7-ene were dissolved in 3 l of THF, and 30 g of 5% Pd/C were added. The mixture was then hydrogenated at atmospheric pressure. The resultant solution was filtered and evaporated to a residue. The residue was recrystallized twice from 200 ml of hexane at -60° C., giving 8-(3-fluorophenyl)-1,4-dioxaspiro[4.5]decane.

後処理

  1. filtrationThe resultant solution was filtered
  2. customevaporated to a residue
  3. customThe residue was recrystallized twice from 200 ml of hexane at -60° C.

出典と根拠

ORDレコード
ord-ce8188fdc4a44c5789d1e380baaf7089
出典データセット
uspto-grants-2000_05
特許番号
US06057006

反応ノート

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