Sodium Hydroxide → 5-Hydroxy-2-methoxypyridine

HRID 1106607

反応式

HRID 1106607 の反応式
C([O:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH3:12])=[N:9][CH:10]=1)(=O)C.[OH-].[Na+]>CO>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH3:12])=[N:9][CH:10]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 224515665-Acetoxy-2-methoxypyridine

生成物 1

HCID 116223355-Hydroxy-2-methoxypyridine収率 53.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of the 5-acetoxy-2-methoxypyridine(600 mg, 3.59 mmol) in MeOH(10 mL) was added 1M aq. NaOH(10 mL, 10 mmol). After stirring at r.t. for 30 min, volatile solvent was removed in vacuo, acidified with HOAc and extracted with CHCl3(3 x). The combined CHCl3 extracts were washed with H2O, dried(anhydrous MgSO4) and evaporated to give the title compound as a brown oil(240 mg, solidified on standing).

後処理

  1. customvolatile solvent was removed in vacuo
  2. extractionextracted with CHCl3(3 x)
  3. washThe combined CHCl3 extracts were washed with H2O, dried(anhydrous MgSO4) and
  4. customevaporated

出典と根拠

ORDレコード
ord-a0fc49c836644fa49a69eaac378a3d51
出典データセット
uspto-grants-2000_05
特許番号
US06057319

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