Menthol → Menthyl acrylate

HRID 1107238ノート

反応式

HRID 1107238 の反応式
[C:1]([OH:5])(=[O:4])[CH:2]=[CH2:3].[CH:6]1([CH3:16])[CH2:11][CH2:10][CH:9]([CH:12]([CH3:14])[CH3:13])[CH:8](O)[CH2:7]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[C:1]([O:5][CH:8]1[CH:9]([CH:12]([CH3:14])[CH3:13])[CH2:10][CH2:11][CH:6]([CH3:16])[CH2:7]1)(=[O:4])[CH:2]=[CH2:3]

参加物

5

反応物 3

HCID 1254MentholHCID 6101p-Toluenesulfonic acidHCID 6581Acrylic Acid

生成物 1

HCID 544164Menthyl acrylate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
150 °C

実験手順

26 g of acrylic acid, 24 g of menthol and 15 g of p-toluenesulfonic acid in 500 mL of toluene were heated under reflux at an oil temperature of 150° C. for 19 h. Subsequently, the reaction mixture was quenched by the addition of salt saturated sodium bicarbonate solution. The mixture was then extracted with ether, the organic layers were combined and washed with salt saturated sodium bicarbonate solution and then with an aqueous solution of sodium hydride, salt saturated ammonium chloride solution, and then dried over salt saturated brine and sodium sulfate anhydrous. Finally, the resultant oily product was evaporated under reduced pressure to obtain menthyl acrylate.

後処理

  1. customSubsequently, the reaction mixture was quenched by the addition of salt saturated sodium bicarbonate solution
  2. extractionThe mixture was then extracted with ether
  3. washwashed with salt saturated sodium bicarbonate solution
  4. dry with materialwith an aqueous solution of sodium hydride, salt saturated ammonium chloride solution, and then dried over salt saturated brine and sodium sulfate anhydrous
  5. customFinally, the resultant oily product was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-eb87e9a54fb34c629957135dd0006571
出典データセット
uspto-grants-2000_05
特許番号
US06060207

反応ノート

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