Acetone → Methyl 2-(isopropylamino)acetate hydrochloride
反応式
[ClH:1].[CH3:2][O:3][C:4](=[O:7])[CH2:5][NH2:6].[CH3:8][C:9]([CH3:11])=O.[OH-].[Na+]>CO.[Pd]>[ClH:1].[CH3:2][O:3][C:4](=[O:7])[CH2:5][NH:6][CH:9]([CH3:11])[CH3:8]参加物
6
実験手順
Part A: A mixture of glycine methyl ester hydrochloride (3.83 g, 30.5 mmol), acetone (1.77 g, 30.5 mmol) and NaOH (1.22 g, 30.5 mmol) in MeOH (200 mL) was stirred under an atmosphere of hydrogen (1 atm) in the presence of palladium on carbon (10%, 0.4 g) for 24 hours. The reaction was flushed with nitrogen and filtered through a Celite pad, acidified with HCl (1N), dried (MgSO4) and evaporated. Trituration of the residue with Et2O gave N-2-propylglycine methyl ester hydrochloride (1.0 g) as an off-white solid; LRMS (M+H)+ =132.1.
後処理
- customThe reaction was flushed with nitrogen
- filtrationfiltered through a Celite pad
- dry with materialdried (MgSO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-99f47b7a6c2146e1925eb579793ac900
- 出典データセット
- uspto-grants-2000_05
- 特許番号
- US06060462
反応ノート
読み込み中…