7-Aminoindole → HCID 11100239、化合物

HRID 1107443

反応式

HRID 1107443 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[CH:7]2.[S:11]([C:15]1[CH:20]=[CH:19][C:18]([S:21](Cl)(=[O:23])=[O:22])=[CH:17][CH:16]=1)(=[O:14])(=[O:13])[NH2:12]>N1C=CC=CC=1>[NH:9]1[C:10]2[C:6](=[CH:5][CH:4]=[CH:3][C:2]=2[NH:1][S:21]([C:18]2[CH:17]=[CH:16][C:15]([S:11](=[O:14])(=[O:13])[NH2:12])=[CH:20][CH:19]=2)(=[O:23])=[O:22])[CH:7]=[CH:8]1

参加物

4

反応物 2

HCID 1116347-AminoindoleHCID 109561594-Sulfamoylbenzene-1-sulfonyl chloride

生成物 1

HCID 11100239HCID 11100239、化合物収率 63.3%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

The synthesis of the present compound can be carried out according to the process disclosed in JP-A-7-165708. For example, the present compound can be synthesized as follows. After dissolving 264 mg (2 mmol) of 7-amino-1H-indole in pyridine, 767 mg (3 mmol) of 4-sulfamoylbenzenesulfonyl chloride is added thereto under stirring at room temperature. After the mixture is stirred overnight at room temperature, the solvent is evaporated under reduced pressure. Ethyl acetate and 0.2 N hydrochloric acid are added to the resulting residue. The organic layer is separated, washed with water, and dried over magnesium sulfate, followed by evaporation of the solvent. The resulting residue is purified by silica gel column chromatography to give 445 mg of N-(1H-indol-7-yl)-4-sulfamoylbenzenesulfonamide.

後処理

  1. customThe synthesis of the present compound
  2. additionis added
  3. stirringAfter the mixture is stirred overnight at room temperature
  4. customthe solvent is evaporated under reduced pressure
  5. additionEthyl acetate and 0.2 N hydrochloric acid are added to the resulting residue
  6. customThe organic layer is separated
  7. washwashed with water
  8. dry with materialdried over magnesium sulfate
  9. customfollowed by evaporation of the solvent
  10. customThe resulting residue is purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-43a8760c721b4de49c9f488aa7441b9f
出典データセット
uspto-grants-2000_05
特許番号
US06060498

関連ノート

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