Water → Methyl 2-(prop-2-en-1-yloxy)benzoate
反応式
[CH2:1](Br)[CH:2]=[CH2:3].[C:5]([O:14][CH3:15])(=[O:13])[C:6]1[C:7](=[CH:9][CH:10]=[CH:11][CH:12]=1)[OH:8].C(=O)([O-])[O-].[K+].[K+].O>C1COCC1.CN(C=O)C>[CH2:1]([O:8][C:7]1[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=1[C:5]([O:14][CH3:15])=[O:13])[CH:2]=[CH2:3]参加物
7
実験手順
A mixture of allyl bromide (152.4 g, 1.27 mol), methyl salicylate (162.44 g, 1.06 mol), and potassium carbonate (219.75 g, 1.59 mol) in THF (600 ml) and DMF (600 ml) was heated to reflux for 6 hr. The mixure was poured into water (3 L) and extracted with ethyl acetate three times. The ethyl acetate extracts were combined and washed with water and dried with brine. The ethyl acetate extracts were concentrated in vacuo to a yellow oil that was vacuum distilled to a clear oil (163.45 g, 80%).
後処理
- temperaturewas heated
- temperatureto reflux for 6 hr
- extractionextracted with ethyl acetate three times
- washwashed with water
- dry with materialdried with brine
- concentrationThe ethyl acetate extracts were concentrated in vacuo to a yellow oil that
- distillationdistilled to a clear oil (163.45 g, 80%)
出典と根拠
- ORDレコード
- ord-daa66a336b9a4fa6bb688c4c67682299
- 出典データセット
- uspto-grants-2000_05
- 特許番号
- US06060506
反応ノート
読み込み中…