Methyl Palmitate → HCID 15405886、化合物

HRID 1107606

反応式

HRID 1107606 の反応式
[C:1]([O:18]C)(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[OH:20][CH2:21][CH2:22][O:23][CH2:24][CH2:25][NH:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42].C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)(Cl)Cl>[CH2:27]([N:26]([CH2:25][CH2:24][O:23][CH2:22][CH2:21][OH:20])[C:1](=[O:18])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42]

参加物

5

反応物 3

HCID 8181Methyl PalmitateHCID 10340Sodium CarbonateHCID 9996690N-(2-hydroxyethoxy)ethyl-n-hexadecylamine

生成物 1

HCID 15405886HCID 15405886、化合物収率 82%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

反応条件

温度
120 °C

実験手順

Into a 250 ml-flask equipped with reflux condenser, were introduced 14.3 g of methyl palmitate and 16.5 g of N-(2-hydroxyethoxy)ethyl-n-hexadecyl amine prepared in Example 1, and thereto was added 2.6 g of sodium carbonate. Then, the mixture was stirred violently for 3 hours at 120° C. After the termination of the reaction, the mixture was cooled to a room temperature and 100 ml of chloroform was added thereto to be dissolved. The precipitates were removed and the solvent was evaporated off under reduced pressure. The produced solid was recrystallized from hexane to give 23.2 g of the title compound(Yield: 82%) as white powder, which was identified by IR and NMR. The results are shown in Table 1.

後処理

  1. customInto a 250 ml-flask equipped
  2. temperaturewith reflux condenser
  3. customAfter the termination of the reaction
  4. temperaturethe mixture was cooled to a room temperature
  5. dissolutionto be dissolved
  6. customThe precipitates were removed
  7. customthe solvent was evaporated off under reduced pressure
  8. customThe produced solid was recrystallized from hexane

出典と根拠

ORDレコード
ord-6c9600fb39bd4a628153c4c9393e2866
出典データセット
uspto-grants-2000_05
特許番号
US06060612

関連ノート

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