Ethanolamine → 1-(2-Hydroxyethylamino)-2-octadecanol

HRID 1108

反応式

HRID 1108 の反応式
[CH2:1]([CH2:3][NH2:4])[OH:2].C(O)C.[O:8]1[CH:10]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:9]1>O>[OH:2][CH2:1][CH2:3][NH:4][CH2:9][CH:10]([OH:8])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]

参加物

5

反応物 3

HCID 700EthanolamineHCID 702EthanolHCID 238721,2-Epoxyoctadecane

生成物 1

HCID 183322851-(2-Hydroxyethylamino)-2-octadecanol収率 74.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

A 300-ml flask equipped with a stirrer and a dropping funnel was charged with 45.8 g (0.75 mol) of ethanolamine and 9 g of ethanol. While stirring the mixture at 80° C., 13.4 g (50 mmol) of 1,2-epoxyoctadecane were added dropwise over 2 hours. Water was added to the resultant reaction mixture, and white crystals formed were collected by filtration, washed with water and then recrystallized from methanol, thereby obtaining 12.3 g (yield: 74.6%) of the title compound (IIc-1).

後処理

  1. customA 300-ml flask equipped with a stirrer and a dropping funnel
  2. customreaction mixture, and white crystals
  3. customformed
  4. filtrationwere collected by filtration
  5. washwashed with water
  6. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-80c2effe4d3141839b36b2e47237d5ac
出典データセット
uspto-grants-1998_03
特許番号
US05723497

関連ノート

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