Bromoacetonitrile → Methyl 2-(cyanomethyl)-2-methylbutanoate
反応式
[CH3:1][CH:2]([CH2:7][CH3:8])[C:3]([O:5][CH3:6])=[O:4].Br[CH2:10][C:11]#[N:12].C([N-]C(C)C)(C)C.[Li+]>C1COCC1>[C:11]([CH2:10][C:2]([CH3:1])([CH2:7][CH3:8])[C:3]([O:5][CH3:6])=[O:4])#[N:12]参加物
5
実験手順
The reaction of methyl 2-methylbutyrate (13.34 g, 115 mmol) with bromoacetonitrile (16.56 g, 138 mmol) in the presence of lithium diisopropylamide (prepared by treating diisopropylamine (12.78 g, 126.5 mmol) with butyllithium in hexanes (2.5 M, 50.6 mL, 126.5 mmol)) in THF (175 mL), as described above in the preparation of Example 1, gave 16.57 g of the crude product as a dark colored liquid. The crude product was vacuum distilled to give the nitrile (10.85 g, 61%) as a colorless liquid: bp 83-85° C. (10 mmHg).
後処理
- customas described above in the preparation of Example 1
- customgave 16.57 g of the crude product as a dark colored liquid
- distillationdistilled
出典と根拠
- ORDレコード
- ord-63a25fedce88442fa5f9e113d40f3cd4
- 出典データセット
- uspto-grants-2000_05
- 特許番号
- US06066666
反応ノート
読み込み中…