Iodoethane → HCID 21257568、化合物

反応式

[H-].[Na+].[C:3]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[N:12]=1)([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4].[CH2:18](I)[CH3:19]>CN(C=O)C>[C:3]([N:10]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[N:12]=1)[CH2:18][CH3:19])([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4]

参加物

反応条件

温度: 0 °C

実験手順

To a suspension of NaH (60% dispersion in mineral oil, 1.15 g, 29.5 mmol) i.l DMF (50 mL) at 0° C. was added a solution of 2-(N-Boc-amino)-6-picoline in DMF (30 mL). The reaction was stirred at 0° C. for 15 min; then ethyl iodide (4.6 g, 30 mmol) was added. The reaction mixture was stirred at RT overnight; then was concentrated in vacuum. The residue was diluted with H2O and extracted with CH2Cl2 (3×50 mL). Drying (MgSO4), concentration, and silica gel chromatography (20% EtOAc/hexane) gave the title compound as colorless oil: MS (ES) m/e 237 (M+H)+.