Diethyl Carbonate → HCID 69967939、化合物
反応式
C([N:8]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13](C)[N:12]=1)[CH2:9][CH3:10])(OC(C)(C)C)=O.C(=O)([O:22][CH2:23][CH3:24])OCC>C1COCC1>[CH2:9]([NH:8][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH:23]([OH:22])[CH3:24])[N:12]=1)[CH3:10]参加物
4
反応条件
- 温度
- -78 °C
実験手順
Ethyl 2-(N-Boc-N-ethylamino)-6-pyridylacetate LDA (0.018 mol) was prepared in THF (30 mL), cooled to -78° C., and 2-(N-Boc-N-ethylamino)-6-picoline (3.5 g, 15 mmol) was added, forming a deep red solution. After 15 min, diethyl carbonate (2.2 mL, 17.9 mmol) was added, the burgundy-colored solution was stirred at -78° C. for an additional 15 min, then the reaction was quenched with saturated NH4Cl. The mixture was warmed to RT and extracted with EtOAc(3×30 mL). The combined organic layers were washed with brine, dried (MgSO4), and concentrated. Silica gel chromatography (10% EtOAc/hexane) gave the title compound as colorless oil: MS (ES) m/e 309 (M+H)+.