Water → 2-p-Tolylbenzoxazole

HRID 1111088

反応式

HRID 1111088 の反応式
[C:1]1([CH3:9])[CH:6]=[CH:5][C:4]([CH:7]=[O:8])=[CH:3][CH:2]=1.[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1O.O.C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.[Pb+4]>C1(C)C=CC=CC=1>[CH3:9][C:1]1[CH:6]=[CH:5][C:4]([C:7]2[O:8][C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[N:10]=2)=[CH:3][CH:2]=1

参加物

6

反応物 4

HCID 962WaterHCID 58012-AminophenolHCID 77254-MethylbenzaldehydeHCID 178418268HCID 178418268、化合物

生成物 1

HCID 700392-p-Tolylbenzoxazole

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 120.2 g (1 mole) of 4-tolualdehyde and 109.1 g (1 mole) of 2-aminophenol in toluene is heated at reflux with azeotropic removal of water. After 20 hours at reflux, the reaction is cooled to room temperature, then 443.4 g (1 mole) of lead tetraacetate is added, and the mixture is stirred at room temperature for 20 hours. The solids are removed by filtration, and the filtrate is swirled with basic alumina. Removal of the solvent in vacuo affords the solid product which is then purified by recrystallization from ethanol.

後処理

  1. temperatureAfter 20 hours at reflux
  2. customThe solids are removed by filtration
  3. customRemoval of the solvent in vacuo
  4. customaffords the solid product which
  5. customis then purified by recrystallization from ethanol

出典と根拠

ORDレコード
ord-7d9256f518ab4910a69dd2dc707f9056
出典データセット
uspto-grants-1990_12
特許番号
US04978476

関連ノート

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