1,1'-Carbonyldiimidazole → 9-chloro-1(dimethylaminoethyl)-7-phenylpyrimido[1,2-a][1,4]-benzodiazepin-3(5H)-one

HRID 1111210

反応式

HRID 1111210 の反応式
[C:1]([N:8]1[CH:12]=[CH:11]N=[CH:9]1)(N1C=CN=C1)=O.[NH2:13][C:14]1[CH2:20][N:19]=[C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:17]2[CH:27]=[C:28]([Cl:31])[CH:29]=[CH:30][C:16]=2[N:15]=1.[O:32]1C[CH2:35][CH2:34][CH2:33]1.CN(C)C=O>>[Cl:31][C:28]1[CH:29]=[CH:30][C:16]2[N:15]3[C:35]([CH2:11][CH2:12][N:8]([CH3:1])[CH3:9])=[CH:34][C:33](=[O:32])[N:13]=[C:14]3[CH2:20][N:19]=[C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:17]=2[CH:27]=1

参加物

4

反応物 3

HCID 682631,1'-CarbonyldiimidazoleHCID 165626N-Desmethyl-N(4)-desoxychlordiazepoxideHCID 21974620tetrahydrofuran N,N-dimethylformamide

生成物 1

HCID 221537269-chloro-1(dimethylaminoethyl)-7-phenylpyrimido[1,2-a][1,4]-benzodiazepin-3(5H)-one

実験手順

In the manner given in Example 16, carbonyldiimidazole, 4-dimethylamino-butyn-2-oic acid and 2-amino-7-chloro-5-phenyl-3H-1,4-benzodiazepine was stirred in tetrahydrofuran-dimethylformamide to give 9-chloro-1(dimethylaminoethyl)-7-phenylpyrimido[1,2-a][1,4]-benzodiazepin-3(5H)-one.

出典と根拠

ORDレコード
ord-2af7079530fa421d8f6674cac9a77390
出典データセット
uspto-grants-1990_12
特許番号
US04978753

関連ノート

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