Ammonium formate → 2,2-Dimethyl-1,3-dioxan-5-amine

HRID 1111256ノート

反応式

HRID 1111256 の反応式
[CH3:1][C:2]1([CH3:11])[O:7][CH2:6][CH:5]([N+:8]([O-])=O)[CH2:4][O:3]1.C([O-])=O.[NH4+]>CO.[Pd]>[CH3:1][C:2]1([CH3:11])[O:7][CH2:6][CH:5]([NH2:8])[CH2:4][O:3]1

参加物

5

反応物 2

HCID 2723923Ammonium formateHCID 108774282,2-Dimethyl-5-nitro-1,3-dioxane

生成物 1

HCID 117686082,2-Dimethyl-1,3-dioxan-5-amine収率 70.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

220 mg 5% Pd/C was added to a solution of 500 mg 2,2-dimethyl-5-nitro-1,3-dioxane (3.1 mmoles) in 30 ml methanol. Ammonium formate (985 mg, 15.6 mmoles) was then added, and the mixture was refluxed for three hours. The reaction solution was then filtered, and the filtrate concentrated in vacuo to yield 286 mg 2,2-dimethyl-5-amino-1,3-dioxane (70% yield).

後処理

  1. temperaturethe mixture was refluxed for three hours
  2. filtrationThe reaction solution was then filtered
  3. concentrationthe filtrate concentrated in vacuo

出典と根拠

ORDレコード
ord-42e6471954b34b13ba19fe924c582782
出典データセット
uspto-grants-1990_12
特許番号
US04978793

反応ノート

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