Benzene → N-(2,2-dipropoxyethyl)-N-(4-methyl-1,3-dioxolan-2-ylmethyl)-alpha-chloroacetamide

HRID 1111562ノート

反応式

HRID 1111562 の反応式
[CH2:1]([O:4][CH:5]([O:15][CH2:16][CH2:17][CH3:18])[CH2:6][NH:7][CH2:8][CH:9]1[O:13][CH:12]([CH3:14])[CH2:11][O:10]1)[CH2:2][CH3:3].C1C=CC=CC=1.C(=O)([O-])[O-].[Na+].[Na+].[Cl:31][CH2:32][C:33](Cl)=[O:34]>O>[CH2:16]([O:15][CH:5]([O:4][CH2:1][CH2:2][CH3:3])[CH2:6][N:7]([CH2:8][CH:9]1[O:13][CH:12]([CH3:14])[CH2:11][O:10]1)[C:33](=[O:34])[CH2:32][Cl:31])[CH2:17][CH3:18]

参加物

6

反応物 4

HCID 241BenzeneHCID 6577Chloroacetyl chlorideHCID 10340Sodium CarbonateHCID 22766279N-(2,2-dipropoxyethyl)-N-(4-methyl-1,3-dioxolan-2-ylmethyl)amine

生成物 1

HCID 22766285N-(2,2-dipropoxyethyl)-N-(4-methyl-1,3-dioxolan-2-ylmethyl)-alpha-chloroacetamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

N-(2,2-Dipropoxyethyl)-N-(4-methyl-1,3-dioxolan-2-ylmethyl)amine (0.05 mole), benzene (100 ml), water (100 ml) and sodium carbonate (2 grams) are charged into a glass reaction vessel equipped with a mechanical stirrer and thermometer. The reaction mixture is cooled to a temperature of from 5° to 10° C and chloroacetyl chloride (0.05 mole) is added dropwise with stirring. After the addition is completed stirring is continued until the reaction mixture has reached room temperature. After this time the organic phase is separated from the aqueous phase and is washed with water. The washed solution is then dried over anhydrous magnesium sulfate, filtered and stripped of solvent under reduced pressure to yield the desired product N-(2,2-dipropoxyethyl)-N-(4-methyl-1,3-dioxolan-2-ylmethyl)-α-chloroacetamide as the residue.

後処理

  1. customequipped with a mechanical stirrer
  2. additionis added dropwise
  3. additionAfter the addition
  4. stirringis completed stirring
  5. customhas reached room temperature
  6. customAfter this time the organic phase is separated from the aqueous phase
  7. washis washed with water
  8. dry with materialThe washed solution is then dried over anhydrous magnesium sulfate
  9. filtrationfiltered

出典と根拠

ORDレコード
ord-27b0756a666645448ce14d345f0b7e62
出典データセット
uspto-grants-1978_10
特許番号
US04118216

反応ノート

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