Hydroxyamine hydrochloride → 4-Amino-phenylcarbamoyl-acetohydroxamic acid hydrochloride
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([CH2:11][C:12]([O:14]CC)=O)=[O:10])=[CH:4][CH:3]=1.[ClH:17].[NH2:18][OH:19].[Na]>CO>[ClH:17].[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([CH2:11][C:12]([NH:18][OH:19])=[O:14])=[O:10])=[CH:4][CH:3]=1参加物
5
実験手順
A mixture of 17.8 g (0.08 mol) of ethyl 4-amino-phenylcarbamoylacetate, 7 g (0.1 mol) of hydroxylamine hydrochloride and 4.6 g (0.2 gram atom) of sodium in 250 ml of anhydrous methanol is left in contact for 2 hours at 20° C. The methanol is evaporated in vacuo, the residue is taken up in 100 ml of water and acidified with 6 N HCl and the product is filtered off. Recrystallisation from 80 ml of water gives CRL 40,472. Melting point 164°-165° C. (with decomposition). Yield: 64%.
後処理
- customThe methanol is evaporated in vacuo
- filtrationthe product is filtered off
- customRecrystallisation from 80 ml of water
- customgives CRL 40,472
出典と根拠
- ORDレコード
- ord-2369ab4bd45c4fb589299c76641403cf
- 出典データセット
- uspto-grants-1978_10
- 特許番号
- US04122186
反応ノート
読み込み中…