Water → 1-Trityl-1H-1,2,4-triazole

HRID 11231

反応式

HRID 11231 の反応式
[H-].[Na+].[NH:3]1[CH:7]=[N:6][CH:5]=[N:4]1.[C:8](Cl)([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.O>CCCCCC.CN(C=O)C>[C:8]([N:3]1[CH:7]=[N:6][CH:5]=[N:4]1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

参加物

7

反応物 4

HCID 962WaterHCID 6456Trityl chlorideHCID 92571H-1,2,4-TriazoleHCID 24758Sodium hydride

生成物 1

HCID 46382511-Trityl-1H-1,2,4-triazole収率 47%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒2 回HCID 8058Hexane溶媒

実験手順

Sodium hydride (60% dispersion in mineral oil, 13.8 g, 345 mmol) was washed with hexane and suspended in DMF (150 ml). At an ice bath temperature, 1,2,4-triazole (total; 20.7 g, 300 mmol) was added thereto in four divisions. After stirring for 30 minutes, to the mixture was added tritylchloride (total; 83.7 g, 300 mmol) in seven divisions and additionally added DMF (50 ml). After stirring for 1.5 hours at room temperature, to the reaction mixture was added water (600 ml). The precipitated crystal was collected by filteration, washed with water, dissolved in CHCl3 (800 ml) and dried. The solvent was evaporated. The obtained residue was chromatographed on silica gel (ethylacetate:CHCl3=1:2, v/v). The fraction of the objective was concentrated to give 1-trityl-1H-1,2,4-triazole (43.9 g). Yield: 47%.

後処理

  1. stirringAfter stirring for 1.5 hours at room temperature, to the reaction mixture
  2. customThe precipitated crystal was collected by filteration
  3. washwashed with water
  4. dissolutiondissolved in CHCl3 (800 ml)
  5. customdried
  6. customThe solvent was evaporated
  7. customThe obtained residue was chromatographed on silica gel (ethylacetate
  8. concentrationThe fraction of the objective was concentrated

出典と根拠

ORDレコード
ord-7128cd1309b044118228bc991451e2cd
出典データセット
uspto-grants-2006_08
特許番号
US07098201B2

関連ノート

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