Pyridine → 2-[5-(3,4-Dimethoxyphenylacetylamino)-2-ethoxyphenyl]-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

HRID 11279

反応式

HRID 11279 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:24][CH2:25][CH3:26])=[C:6]([C:8]2[NH:13][C:12](=[O:14])[C:11]3=[C:15]([CH3:23])[N:16]=[C:17]([CH:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)[N:10]3[N:9]=2)[CH:7]=1.[CH3:27][O:28][C:29]1[CH:30]=[C:31]([CH2:37][C:38](Cl)=[O:39])[CH:32]=[CH:33][C:34]=1[O:35][CH3:36].N1C=CC=CC=1>O1CCCC1>[CH3:27][O:28][C:29]1[CH:30]=[C:31]([CH2:37][C:38]([NH:1][C:2]2[CH:3]=[CH:4][C:5]([O:24][CH2:25][CH3:26])=[C:6]([C:8]3[NH:13][C:12](=[O:14])[C:11]4=[C:15]([CH3:23])[N:16]=[C:17]([CH:18]5[CH2:22][CH2:21][CH2:20][CH2:19]5)[N:10]4[N:9]=3)[CH:7]=2)=[O:39])[CH:32]=[CH:33][C:34]=1[O:35][CH3:36]

参加物

5

反応物 3

HCID 1049PyridineHCID 3604458(3,4-Dimethoxyphenyl)acetyl chlorideHCID 1356049412-(5-Amino-2-ethoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

生成物 1

HCID 1356049512-[5-(3,4-Dimethoxyphenylacetylamino)-2-ethoxyphenyl]-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Analogously to the preparation of example 46, 100 mg (0.283 mmol) of the compound from example 42A are reacted with 182 mg (0.849 mmol) of 3,4-dimethoxyphenylacetyl chloride and 0.23 ml (2.84 mmol) of pyridine in 6 ml of tetrahydrofuran.

出典と根拠

ORDレコード
ord-0d637d190c36455992e0de19f9749e14
出典データセット
uspto-grants-2006_08
特許番号
US07098207B2

関連ノート

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