反応式
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].ClC(Cl)(Cl)[C:12]([N:14]=C=O)=[O:13].N>C(#N)C.CO>[NH2:14][C:12]([NH:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8])=[O:13]参加物
6
実験手順
2-Amino-3-thiophencarboxamide (0.44 g) was suspended in acetonitrile (25 ml) and trichloroacetylisocyanate (0.2 ml) added dropwise with stirring over 10 minutes. Stirring was continued for a further 3 h at room temperature and then a solution of ammonia in methanol (10 ml of a 2M solution) was added and stirring was continued for a further 2 h. The solvent was evaporated and the residue treated with water. The resultant solid was filtered off and washed with more water. Trituration with ether gave the title urea (0.2 g).
後処理
- stirringStirring
- waitwas continued for a further 3 h at room temperature
- stirringstirring
- waitwas continued for a further 2 h
- customThe solvent was evaporated
- additionthe residue treated with water
- filtrationThe resultant solid was filtered off
- washwashed with more water
出典と根拠
- ORDレコード
- ord-f0c8411110a14024be0381e63896f360
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07098240B2
関連ノート
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