3-(4-Fluorophenyl)-2,1-benzisoxazole → 2-Amino-4'-fluorobenzophenone

HRID 1148

反応式

HRID 1148 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][N:10]=[C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=23)=[CH:4][CH:3]=1>O1CCCC1.C(N(CC)CC)C.[Pd]>[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[C:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)=[O:9]

参加物

5

反応物 1

HCID 196948213-(4-Fluorophenyl)-2,1-benzisoxazole

生成物 1

HCID 98372872-Amino-4'-fluorobenzophenone

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒HCID 8471Triethylamine溶媒

実験手順

To a suspension of (16) (42.6 g, 0.2 mol) in 750 ml of dry tetrahydrofuran (THF) and 20 ml of triethylamine is added 5% palladium on charcoal (6 g). The vigorously stirred suspension is flushed with hydrogen gas and stirred at room temperature under a hydrogen atmosphere until absorption of hydrogen ceases (approximately 90-90% of the molar amount; 8-10 hours). The catalyst is removed by filtration through a bed of celite, and the solvent is removed under reduced pressure. The product (16) is recrystallized from toluene.

後処理

  1. customThe vigorously stirred suspension is flushed with hydrogen gas
  2. custom8-10 hours
  3. customThe catalyst is removed by filtration through a bed of celite
  4. customthe solvent is removed under reduced pressure
  5. customThe product (16) is recrystallized from toluene

出典と根拠

ORDレコード
ord-92bc8cb4ed55424491eb833aaed1c16a
出典データセット
uspto-grants-1998_03
特許番号
US05723573

関連ノート

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