反応式
[CH3:1][CH:2]([CH3:19])[CH2:3][N:4]1[C:12]2[NH:11]C=[N:9][C:8]=2[C:7](=[O:13])[N:6]2[CH2:14][C:15]([CH3:18])([CH3:17])[N:16]=[C:5]12.Cl.CSC1NCC(C)(C)N=1.CC(C)CN.ClC1C=CC(CN)=CC=1.N(=C(C#N)C(OCC)=O)[OH:45].S(S([O-])(=O)=O)([O-])(=O)=O.[Na+].[Na+].[OH-].[Na+]>C(O)=O>[NH2:11][C:12]1[N:4]([CH2:3][CH:2]([CH3:19])[CH3:1])[C:5]2[N:6]([CH2:14][C:15]([CH3:18])([CH3:17])[N:16]=2)[C:7](=[O:13])[C:8]=1[N:9]=[O:45]参加物
9
反応物 7
生成物 1
試薬・触媒・溶媒 1
実験手順
6,7-DIHYDRO-4-(2METHYLPROPYL)-6,6-DIMETHYL-3H-IMIDAZO[1,2-a]PURIN-9(4H)-ONE.-- 7-Amino-2,3-dihydro-2,2-dimethyl-8-(2-methylpropyl)-6-nitrosoimidazo[1,2-a]pyrimidin-5(8H)-one was prepared by reaction of the 2-methylthio-4,4-dimethyl-2-imidazoline hydrochloride with 2-methylpropylamine according to the method of Procedure 103 by substitution of the latter for p-chlorobenzylamine. The reaction product from this step was then condensed with ethyl oximinocyanoacetate as described in Procedure 103. The resulting nitroso compound was then reduced with sodium dithionate in formic acid and the resulting formylamino compound was cyclized with dilute aqueous sodium hydroxide according to Procedure 100.
出典と根拠
- ORDレコード
- ord-919ec093ce254ff6b83298a0c56dee4c
- 出典データセット
- uspto-grants-1981_11
- 特許番号
- US04298734
関連ノート
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