Sodium Hydroxide → 2-Aminobenzyl alcohol

HRID 1155331

反応式

HRID 1155331 の反応式
O=C1[NH:7][C:6]2[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=2[CH2:4][O:3]1.[OH-].[Na+]>C(OC(C)C)(=O)C.O>[NH2:7][C:6]1[CH:8]=[CH:9][CH:10]=[CH:11][C:5]=1[CH2:4][OH:3]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 257861,4-Dihydro-2H-3,1-benzoxazin-2-one

生成物 1

HCID 214392-Aminobenzyl alcohol

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 7915Isopropyl Acetate溶媒

反応条件

温度
45 °C

実験手順

The reaction mixture from Stage A was boiled so as to drive off the isopropyl acetate solvent. A solution of 100 g of sodium hydroxide in 100 ml of water was added to the residue, and the whole was refluxed for 2 hours. After cooling to 45° C., the product was extracted with four 270 ml portions of isopropyl acetate. The isopropyl acetate was then distilled off and the product recrystallized from toluene to give 100 g (63% of theoretical) of 97-98% pure 2-amino-benzyl alcohol; m.p. 83°-83.5° C.

後処理

  1. temperaturethe whole was refluxed for 2 hours
  2. extractionthe product was extracted with four 270 ml portions of isopropyl acetate
  3. distillationThe isopropyl acetate was then distilled off
  4. customthe product recrystallized from toluene

出典と根拠

ORDレコード
ord-caa27b79386f449a895ea5d3d2f83872
出典データセット
uspto-grants-1981_11
特許番号
US04301283

関連ノート

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