m-Chloroperbenzoic acid → HCID 20561000、化合物

HRID 1155522ノート

反応式

HRID 1155522 の反応式
ClC1C=C(C=CC=1)C(OO)=[O:6].[Cl:12][C:13]1[CH:22]=[C:21]2[C:16]([C:17](=[O:27])[C:18]([S:24]([CH3:26])=[O:25])=[CH:19][N:20]2[CH3:23])=[CH:15][CH:14]=1>C(Cl)(Cl)Cl>[Cl:12][C:13]1[CH:22]=[C:21]2[C:16]([C:17](=[O:27])[C:18]([S:24]([CH3:26])(=[O:6])=[O:25])=[CH:19][N:20]2[CH3:23])=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 202591227-Chloro-1-methyl-3-(methylsulfinyl)-4(1H)-quinolinone

生成物 1

HCID 20561000HCID 20561000、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

A solution of 3-chloroperoxybenzoic acid (85%, 6.75 g.) in chloroform (70 ml.) was added dropwise to a stirred solution of 7-chloro-1-methyl-3-methylsulphinyl-4-quinolone (6.25 g.) in chloroform (150 ml.). The resulting solution was stirred at room temperature for 2 hours and then washed repeatedly with saturated aqueous sodium carbonate solution to remove peroxide. The resulting solution was dried over anhydrous magnesium sulphate and then evaporated. The solid residue was crystallised from ethanol using charcoal to give 7-chloro-1-methyl-3-methylsulphonyl-4-quinolone, m.p. 241°-242°.

後処理

  1. washwashed repeatedly with saturated aqueous sodium carbonate solution
  2. customto remove peroxide
  3. dry with materialThe resulting solution was dried over anhydrous magnesium sulphate
  4. customevaporated
  5. customThe solid residue was crystallised from ethanol

出典と根拠

ORDレコード
ord-583592bfb1e041c3ab78cc346d5a5aef
出典データセット
uspto-grants-1981_11
特許番号
US04302460

反応ノート

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