Nitric Acid → Flutamide

HRID 1155579

反応式

HRID 1155579 の反応式
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([CH:12]=[CH:13][CH:14]=1)[NH:6][C:7](=[O:11])[CH:8]([CH3:10])[CH3:9].OS(O)(=O)=O.O=S(=O)=O.[N+:26]([O-])([OH:28])=[O:27]>O>[F:1][C:2]([F:15])([F:16])[C:3]1[CH:4]=[C:5]([CH:12]=[CH:13][C:14]=1[N+:26]([O-:28])=[O:27])[NH:6][C:7](=[O:11])[CH:8]([CH3:10])[CH3:9]

参加物

5

反応物 3

HCID 944Nitric AcidHCID 24681Fuming sulfuric acidHCID 1372643-Trifluoromethylisobutyranilide

生成物 1

HCID 3397Flutamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
5 °C

実験手順

Add portion-wise 57.5 g. of m-trifluoromethyl isobutyranilide to 260 ml. of 15-18% oleum while maintaining the internal temperature at about 5° C. To this mixture add drop-wise 20 g. of 90% nitric acid with stirring. Stir at about 5° C. for 2 hours and pour into about 11/2 liters of ice and water with stirring. Collect the 3'-trifluoromethyl-4'-nitro-isobutyranilide by filtration and wash with water until substantially free of excess acid.

後処理

  1. additionAdd portion-wise 57.5 g
  2. additionTo this mixture add drop-wise 20 g
  3. stirringwith stirring
  4. customCollect the 3'-trifluoromethyl-4'-nitro-isobutyranilide
  5. filtrationby filtration
  6. washwash with water until substantially free of excess acid

出典と根拠

ORDレコード
ord-3bb1905416d647b5a51cf2e60bb04d16
出典データセット
uspto-grants-1981_11
特許番号
US04302599

関連ノート

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