Dimethylformamide → 2-(2-Methoxyphenyl)-2-methylpropanenitrile

反応式

[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[CH2:5][C:6]#N.[CH3:12]I.[H-].[Na+].C[N:17]([CH3:20])C=O>>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5]([C:20]#[N:17])([CH3:12])[CH3:6]

参加物

反応物 4

HCID 6228Dimethylformamide

HCID 6328Methyl iodide

HCID 24758Sodium hydride

HCID 81496(2-Methoxyphenyl)acetonitrile

生成物 1

HCID 101979202-(2-Methoxyphenyl)-2-methylpropanenitrile収率 85%

実験手順

By a method analogous to that of Example 3(a), o-methoxybenzyl cyanide was methylated with methyl iodide and sodium hydride in dimethylformamide to give the desired compound in 85% yield.

出典と根拠

ORDレコード: ord-c455276a076849faa4af107f42988fb5
出典データセット: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04333759

反応ノート

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